abstract：:Injury to the bronchial epithelium in respiratory diseases such as asthma and COPD results in the loss of barrier function and an elevated sensitivity to environmental insults. An increased release of the endogenous cannabinoid, anandamide in response to inhalation of allergen in asthmatic patients has been reported. ...

journal_title：Pharmacological research

authors： Shang VC,O'Sullivan SE,Kendall DA,Roberts RE

更新日期：2016-03-01 00:00:00

abstract：:Isoxanthohumol (IXN), a prenylated flavonoid from hops, exhibits diverse biological activities, e.g. antitumor, antiinflammatory, antioxidant and antiangiogenic. In this study, the effect of IXN is evaluated on two melanoma cell lines with dissimilar molecular background, B16 and A375. The treatment of both cell lines...

journal_title：Pharmacological research

authors： Krajnović T,Kaluđerović GN,Wessjohann LA,Mijatović S,Maksimović-Ivanić D

更新日期：2016-03-01 00:00:00

abstract：:Advanced glycation end-products (AGE) and the receptor for AGE (RAGE) have been linked to numerous diabetic vascular complications. RAGE activation promotes a self-sustaining state of chronic inflammation and has been shown to induce apoptosis in various cell types. Although previous studies in vascular smooth muscle ...

journal_title：Pharmacological research

authors： Maltais JS,Simard E,Froehlich U,Denault JB,Gendron L,Grandbois M

更新日期：2016-02-01 00:00:00

abstract：:The blood-brain barrier (BBB) keeps the central nervous system (CNS) safe from various brain diseases, while the BBB makes it difficult for effective drugs to enter the CNS. Mfsd2a is specifically expressed on the cell membrane of brain-microvascular endothelial cell (BMEC) and is implicated in the delivery of some su...

journal_title：Pharmacological research

authors： Wang JZ,Xiao N,Zhang YZ,Zhao CX,Guo XH,Lu LM

更新日期：2016-02-01 00:00:00

abstract：:Ranolazine has characteristic properties of a selective inhibitor of the inward sodium current. It is primarily indicated as an anti-anginal agent in patients with coronary artery disease and chronic stable angina. Recently, ranolazine has been noted to possibly impart beneficial effects in various other cardiac condi...

journal_title：Pharmacological research

authors： Mihos CG,Krishna RK,Kherada N,Larrauri-Reyes M,Tolentino A,Santana O

更新日期：2016-01-01 00:00:00

abstract：:Insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic actions in the heart (i.e., contractility, metabolism, hypertrophy, autophagy, senescence and cell ...

journal_title：Pharmacological research

authors： Westermeier F,Bustamante M,Pavez M,García L,Chiong M,Ocaranza MP,Lavandero S

更新日期：2015-11-01 00:00:00

abstract：:The intestinal barrier function depends on an adequate response to pathogens by the epithelium. Toll-like receptor 3 (TLR-3) recognizes double-stranded RNA, a virus-associated molecular pattern. Activation of TLR-3 with Poly(I:C), a synthetic agonist, modulates tissue repair and permeability in other epithelia; howeve...

journal_title：Pharmacological research

authors： Moyano-Porcile V,Olavarría-Ramírez L,González-Arancibia C,Bravo JA,Julio-Pieper M

更新日期：2015-11-01 00:00:00

abstract：:Disruption of the circadian clock is associated with a variety of human pathologies, including cancer. Rather than being a mere consequence of a global changes associated with the cancer cell transcriptome, the aberrant clock gene expression observed in many tumors may serve for cancer cell survival. This scenario sug...

journal_title：Pharmacological research

authors： Ercolani L,Ferrari A,De Mei C,Parodi C,Wade M,Grimaldi B

更新日期：2015-10-01 00:00:00

abstract：:6-Mercaptopurine is a cytotoxic and immunosuppressant drug. The use of this drug is limited due to its poor bioavailability and short plasma half-life. In order to nullify these drawbacks, 6-mercaptopurine-chitosan nanoparticles (6-MP-CNPs) were prepared and evaluated to study the influence of preparation conditions o...

journal_title：Pharmacological research

authors： Kumar GP,Sanganal JS,Phani AR,Manohara C,Tripathi SM,Raghavendra HL,Janardhana PB,Amaresha S,Swamy KB,Prasad RG

更新日期：2015-10-01 00:00:00

abstract：:Monoclonal antibodies (mAb) have revolutionised the way in which we treat disease. From cancer to autoimmunity, antibody therapy has been responsible for some of the most impressive clinical responses observed in the last 2 decades. A key component of this success has been their generally low levels of toxicity, and u...

journal_title：Pharmacological research

authors： Vaughan AT,Cragg MS,Beers SA

更新日期：2015-09-01 00:00:00

abstract：:Tumor metastasis is a key cause of cancer mortality, and inhibiting migration of cancer cells is one of the major directions of anti-metastatic drug development. Calumenin and fibulin-1 are two extracellular proteins that synergistically inhibit cell migration and tumor metastasis, and could potentially be served as t...

journal_title：Pharmacological research

authors： Zheng P,Wang Q,Teng J,Chen J

更新日期：2015-09-01 00:00:00

abstract：:The ataxin-2 binding protein 1 (A2BP1) gene is reported to be one of the susceptibility genes in schizophrenia, autism, and obesity. The aim of this study was to explore the association of A2BP1 gene polymorphisms with antipsychotic induced weight gain (AIWG) in Chinese Han population. Three hundred and twenty-eight p...

journal_title：Pharmacological research

authors： Dong L,Yan H,Huang X,Hu X,Yang Y,Ma C,Du B,Lu T,Jin C,Wang L,Yu H,Dong Z,Li W,Ruan Y,Zhang H,Zhang H,Mi W,Ma W,Li K,Lv L,Zhang D,Yue W

更新日期：2015-09-01 00:00:00

abstract：:When chemerin was discovered in 1997, it was relegated to being a protein associated with the normal skin function contrasting the setting of psoriasis. However, with the discovery of multiple receptors for the chemerin protein and a vast collection of associations with various pathologies, chemerin has global influen...

journal_title：Pharmacological research

authors： Ferland DJ,Watts SW

更新日期：2015-09-01 00:00:00

abstract：:Psoriasis is one of the most common skin disorders characterized by erythematous plaques that result from hyperproliferative keratinocytes and infiltration of inflammatory leukocytes into dermis and epidermis. Recent studies suggest that IL-23/IL-17A/IL-22 cytokine axis plays an important role in the pathogenesis of p...

journal_title：Pharmacological research

authors： Nadeem A,Al-Harbi NO,Al-Harbi MM,El-Sherbeeny AM,Ahmad SF,Siddiqui N,Ansari MA,Zoheir KM,Attia SM,Al-Hosaini KA,Al-Sharary SD

更新日期：2015-09-01 00:00:00

abstract：:With more than four decades of clinical research and 25 years of clinical trials, much is known about the natural history of T1D before and after clinical diagnosis. We know that autoimmunity occurs early in life, that islet autoimmunity inevitably leads to clinically overt disease, and that some immune therapies can ...

journal_title：Pharmacological research

authors： Lord S,Greenbaum CJ

更新日期：2015-08-01 00:00:00

abstract：:Bleomycin (BLM) is a drug used to treat different types of neoplasms. BLM's most severe adverse effect is lung toxicity, which induces remodeling of lung architecture and loss of pulmonary function, rapidly leading to death. While its clinical role as an anticancer agent is limited, its use in experimental settings is...

journal_title：Pharmacological research

authors： Della Latta V,Cecchettini A,Del Ry S,Morales MA

更新日期：2015-07-01 00:00:00

abstract：:Gap junctions (GJ) mediate electrical coupling between cardiac myocytes, allowing the spreading of the electrical wave responsible for synchronized contraction. GJ function can be regulated by modulation of connexon densities on membranes, connexin (Cx) phosphorylation, trafficking and degradation. Recent studies have...

journal_title：Pharmacological research

authors： Del Ry S,Moscato S,Bianchi F,Morales MA,Dolfi A,Burchielli S,Cabiati M,Mattii L

更新日期：2015-05-01 00:00:00

abstract：:The perioperative period is supposed to be a vulnerable period for cancer progression. Results of clinical studies indicate that the use of regional anesthesia can influence and improve oncological outcome of cancer patients. Uncontrolled cell proliferation and resistance to apoptotic cell death are important characte...

journal_title：Pharmacological research

authors： Bundscherer A,Malsy M,Gebhardt K,Metterlein T,Plank C,Wiese CH,Gruber M,Graf BM

更新日期：2015-05-01 00:00:00

abstract：:Vaccinations have been used as an essential tool in the fight against infectious diseases, and succeeded in improving public health. However, adverse effects, including autoimmune conditions may occur following vaccinations (autoimmune/inflammatory syndrome induced by adjuvants--ASIA syndrome). It has been postulated ...

journal_title：Pharmacological research

authors： Soriano A,Nesher G,Shoenfeld Y

更新日期：2015-02-01 00:00:00

abstract：:Low-doses of fenofibrate and dipyridamole have pleiotropic renoprotective actions in diabetic rats. This study investigated their combined effect relative to their individual treatments and lisinopril in rats with diabetic nephropathy. Streptozotocin (55mg/kg, i.p., once)-administered diabetic rats were allowed for 10...

journal_title：Pharmacological research

authors： Balakumar P,Varatharajan R,Nyo YH,Renushia R,Raaginey D,Oh AN,Akhtar SS,Rupeshkumar M,Sundram K,Dhanaraj SA

更新日期：2014-12-01 00:00:00

abstract：:Statins have, at present, the potential to provide a new therapeutic target for various neurological diseases. It is well established that statins reduce cholesterol levels and prevent coronary heart disease. Moreover, evidence suggest that statins have additional properties such as endothelial protection via action o...

journal_title：Pharmacological research

authors： Malfitano AM,Marasco G,Proto MC,Laezza C,Gazzerro P,Bifulco M

更新日期：2014-10-01 00:00:00

abstract：:HMG-CoA reductase inhibitors (statins) have been shown to improve cardiovascular (CV) outcomes in the general population as well as in patients with cardiovascular disease (CVD). Statins' beneficial effects have been attributed to both cholesterol-lowering and cholesterol-independent "pleiotropic" properties. By their...

journal_title：Pharmacological research

authors： Kassimatis TI,Goldsmith DJ

更新日期：2014-10-01 00:00:00

abstract：:Diarrhea is a common side effect experienced by cancer patients undergoing clinical chemotherapy, such as with 5-fluorouracil (5-FU). However, the precise mechanisms underlying 5-FU-induced diarrhea remain unclear. In the present study, we examined the role of neutrophil in 5-FU-induced diarrhea. Mice were given 5-FU ...

journal_title：Pharmacological research

authors： Sakai H,Sagara A,Matsumoto K,Jo A,Hirosaki A,Takase K,Sugiyama R,Sato K,Ikegami D,Horie S,Matoba M,Narita M

更新日期：2014-09-01 00:00:00

abstract：:Cardiovascular disease (CVD) is the leading cause of death worldwide and the prevalence of obesity and diabetes are increasing. In obesity, adipose tissue increases the secretion of bioactive mediators (adipokines) that may represent a key mechanism linking obesity to CVD. Adiponectin, extensively studied in metabolic...

journal_title：Pharmacological research

authors： Caselli C,D'Amico A,Cabiati M,Prescimone T,Del Ry S,Giannessi D

更新日期：2014-04-01 00:00:00

abstract：:CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease. The aim of the present study was to characterize the electrophysiological and metabolic profile of CHF5074 in the hippocampus. Electrophysiological recordings show that CHF5074 inhibits...

journal_title：Pharmacological research

authors： Mango D,Barbato G,Piccirilli S,Panico MB,Feligioni M,Schepisi C,Graziani M,Porrini V,Benarese M,Lanzillotta A,Pizzi M,Pieraccini S,Sironi M,Blandini F,Nicoletti F,Mercuri NB,Imbimbo BP,Nisticò R

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:The vasorelaxant effect of 2-arachidonoylglycerol (2-AG) has been well characterised in animals. 2-AG is present in human vascular cells and is up-regulated in cardiovascular pathophysiology. However, the acute vascular actions of 2-AG have not been explored in humans. APPROACH:Mesenteric arteries were obtai...

journal_title：Pharmacological research

authors： Stanley CP,O'Sullivan SE

更新日期：2014-03-01 00:00:00

abstract：:Accumulation of amyloid-β peptides (Aβ) within brain is a major pathogenic hallmark of Alzheimer's disease (AD). Emerging evidence suggests that autophagy, an important intracellular catabolic process, is involved in Aβ clearance. Here, we investigated whether temsirolimus, a newly developed compound approved by Food ...

journal_title：Pharmacological research

authors： Jiang T,Yu JT,Zhu XC,Tan MS,Wang HF,Cao L,Zhang QQ,Shi JQ,Gao L,Qin H,Zhang YD,Tan L

更新日期：2014-03-01 00:00:00

abstract：:Selective cyclooxygenase 2 (COX2) inhibitors (COXIBs) are effective anti-inflammatory and analgesic drugs with improved gastrointestinal (GI) safety compared to nonselective nonsteroidal anti-inflammatory drugs known as traditional (tNSAIDs). However, their use is associated with a cardiovascular (CV) hazard (i.e. inc...

journal_title：Pharmacological research

authors： Martelli A,Testai L,Anzini M,Cappelli A,Di Capua A,Biava M,Poce G,Consalvi S,Giordani A,Caselli G,Rovati L,Ghelardini C,Patrignani P,Sautebin L,Breschi MC,Calderone V

更新日期：2013-12-01 00:00:00

abstract：:We aimed to investigate the cardiac changes in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer treated with trastuzumab in an adjuvant setting. Two hundred and fifty-three women with HER2-positive breast cancer were included. The assessment of cardiovascular system and echocardiogr...

journal_title：Pharmacological research

authors： Piotrowski G,Gawor R,Bourge RC,Stasiak A,Potemski P,Gawor Z,Nanda NC,Banach M

更新日期：2013-12-01 00:00:00

abstract：:CYT387 is an orally bioavailable, small molecule inhibitor of Janus family of tyrosine kinases (JAK) 1 and 2. It is currently undergoing Phase I/II clinical trials for the treatment of myelofibrosis and myeloproliferative neoplasms. We aimed to establish whether the multidrug efflux transporters P-glycoprotein (P-gp; ...

journal_title：Pharmacological research

authors： Durmus S,Xu N,Sparidans RW,Wagenaar E,Beijnen JH,Schinkel AH

更新日期：2013-10-01 00:00:00

abstract：:Although calcimimetics were developed to block parathyroid hormone synthesis, some reports suggest that they may also reduce blood pressure by unknown mechanisms. Calcimimetic-induced changes in the synthesis of endothelial vasoactive factors could be involved. Wistar rats were treated with the calcimimetic R-568, and...

journal_title：Pharmacological research

authors： Martínez-Miguel P,Medrano-Andrés D,Lopes-Martín V,Arribas-Gómez I,Rodríguez-Puyol M,Rodríguez-Puyol D,López-Ongil S

更新日期：2013-10-01 00:00:00

abstract：:The mechanisms involved in enhanced cough induced by central and inhaled NGF in guinea pigs were investigated. Cough and airway function were assessed by plethysmography following inhaled or intracerebroventricular (i.c.v.) NGF treatment. Expression of TrkA and/or TRPV1 was determined in bronchi and/or brainstem by re...

journal_title：Pharmacological research

authors： El-Hashim AZ,Jaffal SM,Al-Rashidi FT,Luqmani YA,Akhtar S

更新日期：2013-08-01 00:00:00

abstract：:We have recently synthesized a new series of 4,5-dihydrobenzo-oxa-cycloheptapyrazole derivatives with the aim to discover novel CB1 antagonist agents characterized by anti-obesity activity comparable to that of SR141716A but with reduced adverse effects such as anxiety and depression. Within the novel class, the CB1 a...

journal_title：Pharmacological research

authors： Mastinu A,Pira M,Pinna GA,Pisu C,Casu MA,Reali R,Marcello S,Murineddu G,Lazzari P

更新日期：2013-08-01 00:00:00

abstract：:The available studies have reported the benefits of statins on all-cause and cardiovascular mortality in chronic kidney disease (CKD) patients. However studies in end-stage renal disease patients on dialysis yielded conflicting results. Therefore, we performed a meta-analysis and provide the most reliable trial data t...

journal_title：Pharmacological research

authors： Barylski M,Nikfar S,Mikhailidis DP,Toth PP,Salari P,Ray KK,Pencina MJ,Rizzo M,Rysz J,Abdollahi M,Nicholls SJ,Banach M,Lipid and Blood Pressure Meta-Analysis Collaboration Group.

更新日期：2013-06-01 00:00:00

abstract：:Radiotherapy plays a critical role in the treatment of non-small cell lung cancer (NSCLC). However, radioresistance is a major barrier against increasing the efficiency of radiotherapy for NSCLC. To understand the mechanisms underlying NSCLC radioresistance, we previously focused on the potential involvement of PIM1, ...

journal_title：Pharmacological research

authors： Kim W,Youn H,Kwon T,Kang J,Kim E,Son B,Yang HJ,Jung Y,Youn B

更新日期：2013-04-01 00:00:00

abstract：:Mammals and their intestinal microbiota peacefully coexist in a mutualistic relationship. Commensal bacteria play an active role in shaping and modulating physiological processes in the host, which include, but are not restricted to, the immune system and the intestinal barrier. Both play a crucial role in containing ...

journal_title：Pharmacological research

authors： Natividad JM,Verdu EF

更新日期：2013-03-01 00:00:00

abstract：:Cells continuously turn over proteins through cycles of synthesis and degradation in order to maintain a functional proteome and to exert a tight control in the levels of regulatory proteins. Selective degradation of proteins was initially thought to be an exclusive function of the ubiquitin-proteasome system, however...

journal_title：Pharmacological research

authors： Kaushik S,Cuervo AM

更新日期：2012-12-01 00:00:00

abstract：:A pharmacokinetic study of the metabolic profile of resveratrol has been performed in healthy men after moderate red wine (RW) consumption. The bioavailability of resveratrol is highly influenced by several factors such as the food matrix and, therefore, this study has been compared with a pilot study in which men ing...

journal_title：Pharmacological research

authors： Rotches-Ribalta M,Andres-Lacueva C,Estruch R,Escribano E,Urpi-Sarda M

更新日期：2012-11-01 00:00:00

abstract：:Some bladder disorders, such as obstructive bladder and hyperactivity, may be caused partly by ischemia/reperfusion injury (I/R). The neuroprotective effects of estrogens were demonstrated in in vitro studies and a great interest in soy isoflavones (genistein and daidzein) as alternative to the synthetic estrogen rece...

journal_title：Pharmacological research

authors： Valeri A,Fiorenzani P,Rossi R,Aloisi AM,Valoti M,Pessina F

更新日期：2012-10-01 00:00:00

abstract：:Cocoa contains flavonoids with antioxidant properties. The aim of this study was to ascertain the effect of cocoa intake on oxidative stress associated with a model of chronic inflammation such as adjuvant arthritis. Female Wistar rats were fed with a 5% or 10% cocoa-enriched diet or were given p.o. a quercetin suspen...

journal_title：Pharmacological research

authors： Ramos-Romero S,Pérez-Cano FJ,Ramiro-Puig E,Franch A,Castell M

更新日期：2012-09-01 00:00:00